"The S220 Focused-ultrasonicator is a versatile, high power system engineered for pre-analytical sample processing with Covaris’ patented Adaptive Focused Acoustics™. Utilizing a spherical acoustic transducer, specifically designed AFA™ Tubes, and advanced electronics, AFA delivers controlled energy precisely and accurately to sample volumes from 25 μl to 10 ml..." (see link for further information)

Efficient and smooth DNA shearing is achieved using the Covaris S2 system. The system supports different shearing protocols including chromatin shearing for its application in ChIP-Seq studies.