A fundamental problem in neurobiology is how the multitude of different cells of the brain is generated from their precursors, or stem cells. We study the underlying mechanisms during vertebrate brain development and regeneration.

Our studies will provide clues on how CNS regeneration can be stimulated also in mammalian brains and pave the way for stem cell based regenerative therapies against acute as well as chronic brain injury. 

Future prospects and goals

• Identification of the molecular mechanisms that allow adult CNS regeneration in a regeneration-competent organism to rekindle regeneration in degenerative brain diseases and also in the mammalian CNS
• organizer-dependent patterning and differentiation processes in the embryonic and adult vertebrate brain