Theoretical Biology / Medical System Biology:

• Theoretical concepts of stem cell organization (theoretical stem cell biology):
  • Proliferation- and differentiation control of haematopoietic stem cells
  • Cell fate regulation of mouse embryonic stem cells
  • Clonal competition phenomena
  • Stem cell / niche interaction
• Mathematical models and computer simulation of stem cell development:
  • Single cell(agent)-based models of the stem cell organization
  • Dynamics of molecular regulation networks
• Disease and treatment models / model-based design of clinical trials:
  • Chronic myeloid leukaemia
  • Gene therapeutic approaches

Biostatistics / Bioinformatics:

• Statistical analyse of dynamic processes and structures:
  • Analysis of cellular genealogies (lineage trees)
  • Application of „mixed-effect“ models
• Image analysis / image processing:
  • Single cell tracking and genealogy reconstruction
  • Model-based segmentation methods
• Integratived methods for the analyse of molecular data:
  • (MicroArray-based) gene expression analysis
  • Next-generation sequencing